Research Paper Volume 9, Issue 10 pp 2098—2116

A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis

Figure 4. MYC-RAS co-operativity enhances glycolysis. Extracellular acidification rate (ECAR) was measured in MCF7 cell lines, using the Seahorse XFe96 metabolic flux analyzer. Both (A) ECAR metabolic tracings and (B) Bar graphs are shown. Note that only transduction with c-Myc plus H-Ras (G12V) increases glycolytic rates.