Research Paper Volume 9, Issue 10 pp 2098—2116

A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis

Figure 5. MYC-RAS-induced mammosphere formation remains sensitive to Doxycycline treatment. Note that mammosphere formation in MCF7-H-Ras (G12V) cells is more resistant to Doxycycline, but this can be overcome by using slightly higher dosages.