Research Paper Volume 9, Issue 10 pp 2098—2116

A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis

Figure 6. Rotenone dose-dependently stimulates mammosphere formation, in the low nanomolar range. (A) Concentration range from 0.01 to 100 nM; (B) Concentration range from 0.05 to 5 nM. Note that low-dose Rotenone (1 nM and 2.5 nM) stimulates mammosphere formation, while higher concentrations of Rotenone (10-100 nM) are inhibitory.