Research Paper Volume 9, Issue 10 pp 2098—2116

A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis

Figure 8. Flow-diagram illustrating our overall approach to Myc-driven biomarker discovery. In this analysis, we focused specifically on ER(+) patients, luminal A sub-type, that were lymph-node positive (LN(+)) at diagnosis, who were treated with tamoxifen and followed over a period of nearly 200 months (>15 years). In this context, we evaluated the prognostic value of Myc-related mitochondrial markers for predicting tumor recurrence (RFS) or distant metastasis (DMFS), in this patient population.