Research Paper Volume 9, Issue 10 pp 2098—2116

A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis

Figure 9. A short c-Myc-related mitochondrial signature predicts poor clinical outcome in high-risk ER(+) breast cancer patients. Note that this short 3-gene signature (HSPD1/COX5B/TIMM44) effectively predicts tumor recurrence and distant metastasis in ER(+)/LN(+)/luminal A patients treated with tamoxifen therapy, indicative of treatment failure and tamoxifen-resistance. RFS, recurrence-free survival; DMFS, distant metastasis-free survival.