Figure 2. Aging is associated with cortical porosities, regional variation in mineral density and growth plate closure. (A) microCT reconstruction of distal femur cortical bone in an aged female showing cortical porosity (arrow). (B) BSEM image of the distal femur (Bar = 500μm) and midshaft cortical bone (Bar = 50μm) in young and aged C57BL/6 mice. Arrow indicates growth plate closure in the aged male and * indicates cortical porosities. (C) Quantitation of cortical porosity from n=5 animals showing a significant increase in cortical porosity in female C57BL/6 mice with age.