Research Paper Volume 9, Issue 10 pp 2209—2222

Senescence-associated ultrastructural features of long-term cultures of induced pluripotent stem cells (iPSCs)

Figure 9. Schematic diagram of biological features observed in y-iPSCs, ma- (following 6 months of culture) and a-iPSCs (In particular, we highlighted the mitochondrial disruption, the progressive loss of cell- cell contacts, the presence of autophagosomes and extracellular vesicles with aging. m, mitochondria; N, nucleus; E, extracellular vesicles; A, autophagosomes.