Figure 1. The role of LOXL2 in osteoarthritis and cartilage regeneration: Our studies showed that LOXL2 transduction in vitro and in vivo induces anabolic gene expression [COL2A1, SOX9, ACAN, lysine-specific demethylase 6B (KDM6B), chondroitin sulfate proteoglycan 4 (CSPG4, lubricin)], extracellular matrix (ECM) remodeling and proteoglycan deposition, while attenuating catabolic genes [matrix metalloproteinase 13 (MMP13) and NF-κB signaling]. However, LOXL2 induced specific mechanism and epigenetic regulation during anabolic response are yet to be characterized in details. Increased and decreased level by arrows (up-down) and unknown role (?) are indicated in figure.