Research Paper Volume 9, Issue 12 pp 2489—2503

Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936

Figure 1. (a) Transcriptome-Wide Association Study Manhattan Plot of the paired t-test T-statistic for difference in expression at age 70 and age 76. (b) Density Plot of transcript (Pearson) correlations between ages 70 and 76. The red curve is the correlation distribution for the Bonferroni corrected significant transcripts that either increase or decrease in expression levels with age; the black curve is for all transcripts.