Research Paper Volume 9, Issue 12 pp 2504—2520

Human longevity: 25 genetic loci associated in 389,166 UK biobank participants

Figure 2. LocusZoom plot of the CDKN2A/B/ANRIL gene cluster and known disease variants. Known disease-associated genetic variants have been highlighted in the 9p21.3 region, in addition to the lead SNP identified in our analysis. Association p-values indicate the strength of association with parents' attained age. The variants known to influence coronary artery disease (CAD) and related-traits are those most-associated with parents’ attained age. Variants previously associated with cancer are markedly less associated with parents’ attained age, with type-2 diabetes variants not associated (p>0.05). Details, including references, are included in Supplementary Table 2.