Research Paper Volume 9, Issue 12 pp 2559—2586

Central role of the p53 pathway in the noncoding-RNA response to oxidative stress

Figure 7. ncRNA alterations identified in H2O2-treated ECs are also present in senescent HUVEC. Total RNA was extracted from early and late passage HUVEC and the indicated RNAs were tested by qPCR. The bar graphs represent average values ±SEM (early passage n= 3, late passage n= 7; *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001). (A) ncRNAs. (B) Differential exon usage. Exon 1b isoforms of MDM2 and PVT1 are p53-regulated.