Editorial Volume 9, Issue 12 pp 2455—2456

Targeting oral cancer epigenome via LSD1

Figure 1. The potential role of LSD1 growth, metastasis, and pro-inflammatory response to OSCC: Our studies showed that LSD1 expression or recruitment to chromatin is induced by EGFR- or YAP-induced signaling pathways. LSD1 may induce demethylation of dimethylated H3K4/H3K9 or alter NF-kB signaling, resulting in expression of MMP13, LOXL4, and CTGF. The coordination of different signaling pathways regulated by LSD1 could lead to OSCC growth, metastasis, and a pro-inflammatory response. An LSD1 inhibitor (GSK-LSD1) that attenuates LSD1 function could thereby inhibit OSCC. Unknown roles are indicated by (?).