Editorial Volume 9, Issue 12 pp 2459—2460

TC-PTP nuclear trafficking in keratinocytes

Figure 1. The mechanism of UVB-mediated nuclear translocation of TC45 by the AKT/14-3-3σ axis in keratinocytes. UVB-mediated activation of AKT triggers TC45 phosphorylation on T179, which results in the binding of 14-3-3σ with cytoplasmic TC45 and subsequently, their nuclear translocation. In the nucleus, TC45 dephosphorylates STAT3 before it binds to the promoter regions of its target genes, resulting in the inhibition of the genes necessary for keratinocyte survival and proliferation.