Figure 1. Changes in the S1P and ceramide biosynthesis pathway with increasing CR. Figure modified from IPA, boxplots showing outliers, minimum, maximum and interquartile range values. Red =increased with CR, blue = decreased with CR, white = undetected in our analysis. Metabolite intensities log2 transformed. *=P<0.05, **=P<0.01, ***=P<0.001. Figure taken from Green et al., 2017 .