Figure 1. Functional versitility and pharmacological relevance of CDK1. CDK1 promotes multiple biological processes that are critical for cell survival, including G2/M transition, checkpoint activation, DNA repair, and DNA replication as we propose. Its activities in these processes compromise the efficacy of chemotherapeutic drugs and may contribute to chemoresistance (a). Hence, combining pharmological inhibition of CDK1 with conventionl anti-cancer drugs will potentially enhance toxicity to cancer cells and lead to cell death (b).