Editorial Volume 9, Issue 12 pp 2467—2468

Figure 1. Dynamics of FOXO3 in lymphoblastoid cell lines.Top: Schematic depicting results of separate FISH experiments (HACE1-FOXO3-LAMA4 and ATG5-FOXO3-AMD1) in which, in response to stress (200 µM H₂O₂ and serum deprivation), FOXO3 moved towards the most distant flanking genes (HACE1 and LAMA4, located 3.6 and 3.7 Mb, respectively, from FOXO3) in the 46-gene neighbourhood, as well as towards more proximally located flanking genes (ATG5 and AMD1, located 2.1 and 2.3 Mb, respectively, from FOXO3), resulting in the formation of a tight transcription complex. Bottom: FOXO3 mRNA expression was greater for cell lines containing the longevity-associated G allele of SNP rs2802292 (mean ± SE; P < 0.001).