Research Paper Volume 9, Issue 12 pp 2610—2628

Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy

Figure 12. DPI rapidly induces a reactive glycolytic phenotype. Even with as little as 1 hour of DPI treatment, glycolysis was progressively increased, over a concentration range of 5 to 100 nM, as seen using the Seahorse XFe96 Metabolic Flux Analyzer. Note that glycolysis was effectively doubled.