Editorial Volume 9, Issue 12 pp 2469—2470

VCP represses pathological cardiac hypertrophy

Figure 1. An illustration of the mechanism by which VCP protects against pressure overload induced cardiac hypertrophy. Pressure overload reduces VCP expression which attenuates the inhibitive effect of VCP on AKT/mTORC1/S6K signaling, subsequently promotes the cardiomyocyte hypertrophy.