Research Paper Volume 10, Issue 1 pp 34—55

Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice

Figure 4. mRNA levels of proteins involved in mitochondrial dynamics vary during the aging process. *p<0.05. **p<0.01 ***p<0.001 (A) mRNA levels of Mfn1 significantly increased in the adult group. (B) mRNA levels of Mfn2 are significantly decreased in the older groups (10-14 mo and 16-20 mo) (C) mRNA levels of Opa1 are significantly decreased in the older groups (10-14 mo and 16-20 mo) (D) mRNA levels of Drp1 are significantly decreased in the 10-14 mo group. (E) mRNA levels of Fis1 are significantly decreased in the 10-14 mo group. (F) and (G) Representative Western blots of Drp1 and Opa1 respectively.