Research Paper Volume 10, Issue 1 pp 83—99

Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury

Figure 2. Effects of resveratrol on the renal phenotypes of collagen IV (Col IV), TGF-β1 and F4/80. Immunohistochemical staining with Col IV, TGF-β1, and F4/80 in RSV and control (Cont) groups. Representative images of Col IV and TGF-β1 in aging kidney glomerulus (A, B; original magnification ×400) are shown. In addition, the F4/80-positive cells in glomeruli and F4/80-positive areas in the tubules (C, D; original magnification ×400) are shown. Expression of Col IV and TGF-β1 was decreased in the RSV group (E, F). F4/80-positive cells in glomeruli and positive areas in the tubules were observed as significantly smaller in the RSV group (G, H) (*P<0.001).