Editorial Volume 10, Issue 1 pp 13—14

SLPI: a new target for stopping metastasis

Figure 1. Schematic representation of SLPI effect on the regulation of the FoxM1 target genes and subsequent metastasis. SLPI activates transcriptional factor FoxM1, which stimulates expression of target genes involved in cell division, cell migration, premetastatic niche formation, epithelial–mesenchymal transition, senescence and metastasis.