Figure 1. Metformin prevents rapamycin-induced weight loss in male mice. Body weights over time for (A) male and (B) female HET3 mice fed control (open square) diet or diets containing metformin (open circle), rapamycin (closed square), or both metformin and rapamycin (closed circle). Symbols represent mean values at indicated time point ± SEM. For all groups, n=10. Letters indicate significant difference among groups.