Research Paper Volume 10, Issue 3 pp 434—462

Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence

Figure 4. L1CAM expression is a downstream event linked to inhibition of cyclin-dependent kinases. L1CAM mRNA (A), total protein (B) and surface expression in control cells (ctrl; DOX-) and doxycycline-induced (DOX+) H28 cell clones #5, #34 (expressing p16) and #24 (expressing p21). L1CAM mRNA level was normalized to GAPDH. All experiments were performed in three independent replicates. Scale bar, 100 μm.