**Figure 1.** **Scheme of univariate and pleiotropic meta-analyses in stage 2**. (**A**) Statistics from stage 1 univariate GWAS of 20 phenotypes in five cohorts denoted P*i*C*j*, **B**) Univariate statistics from the meta-analysis across cohorts using the fixed-effects meta-test (P*i*M) and Fisher test (P*i*Fc). (**C**) Statistics from the pleiotropic meta-analysis across phenotypes in cohort *j* for: (i) omnibus tests with correlation matrix for phenotypes *j*) and effect statistics *j*) and (ii) Fisher test (FpC*j*). (**D**) Meta-statistics from Fisher test across cohorts for the results in (**C**) (OpFc, ObFc, and FpFc). (**E**) Meta-statistics across phenotypes for the results in (**B**) from (i) meta-test across cohorts and omnibus test across phenotypes with correlation matrix for phenotypes