Research Paper Volume 10, Issue 5 pp 988—999

A novel functional polymorphism of GFAP decrease glioblastoma susceptibility through inhibiting the binding of miR-139

Figure 4. rs11558961 C>G variant reduced chemoresistance and increased imatinib-induced apoptosis of GBM primary cells. (A) The apoptosis status of cells carrying different genotypes were examined under a fluorescence microscope after Hoechst 33258 staining. (B) Quantification analysis by Image J software. All experiments were performed in triplicate. Data was presented as mean ±SD. Scale Bar = 100μm. *P<0.05, **P<0.01.