Figure 1. Schema illustrating the significance of endothelial GABA mediated signaling for neurovascular interactions and its implications for a wide range of neurological and psychiatric diseases. In addition to the prenatal brain, it is important to gain further insights into mechanisms and functions of this novel GABA pathway in the postnatal, adult and aging brain. Depictions: Endothelial cells (pink), GABAergic neurons (green), GABA (yellow circles).