Research Paper Volume 10, Issue 6 pp 1380—1389

The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells – implication in subretinal immune privilege in the aging eye

Figure 1. Subretinal macrophages in the aging eye. RPE/choroidal flatmount from 18 months (A) and 24 months (B) old CX3CR1gfp/+ mice were stained with phalloidin and imaged by confocal microscopy. Arrows - pigmented debris in subretinal macrophages. (C), RPE/choroidal flatmount from a 24 month old CX3CR1gfp/+ mouse was imaged by confocal microscopy. Green – GFP+ subretinal macrophages; Red – autofluorescence (AF).