Research Paper Volume 10, Issue 6 pp 1390—1401

Five ETS family members, ELF-1, ETV-4, ETV-3L, ETS-1, and ETS-2 upregulate human leukocyte-associated immunoglobulin-like receptor-1 gene basic promoter activity

Figure 1. The location and relative luciferase activities of LAIR-1 truncated promoter constructs. The LAIR-1 gene promoter region and its 15 truncated constructs are presented on the left. The nucleotide positions of each DNA fragment in the constructs are indicated by numbers; the translational start site (TSS) is defined as the +1 position. Relative luciferase activities in HEK293T cells transfected with each truncated construct are presented on the right. Luciferase activities were measured at 48 h after transfection. The results are the mean ± standard deviation of triplicate transfections and are expressed in arbitrary units based on the firefly luciferase activity normalized against the Renilla luciferase activity. The bars present as the mean ± standard deviation of three independent transfection experiments (a, b, c, d, e, f and g indicate significant differences in groups identified with 1-way ANOVA,p<0.05).