Research Paper Volume 10, Issue 6 pp 1442—1453

Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis

Figure 1. α-Klotho expression in mouse embryos during cartilage formation. Serial sections of E13 and E17 mouse embryos were stained with Alcian blue to detect cartilage (A and C) or with an anti- pan α-Klotho antibody (B and D). Arrows are showing cartilaginous tissues expressing also α-Klotho.