Research Paper Volume 10, Issue 6 pp 1442—1453

Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis

Figure 3. Identification of genes regulated by secreted α-Klotho in human chondrocytes. (A) Genome-wide microarray analysis of human primary chondrocytes incubated or not with recombinant secreted α-KL or after siRNA-mediated α-KL silencing identified 748 genes with opposite behavior in these two experimental conditions. FC, fold change. (B) List of the 38 genes (among the common 748 differentially expressed genes) that are involved in osteoarticular diseases according to the Ingenuity® software.