Research Paper Volume 10, Issue 6 pp 1489—1505

Regulatory RNA binding proteins contribute to the transcriptome-wide splicing alterations in human cellular senescence

Figure 3. Pipeline of identifying RNA binding proteins (RBPs) regulating the senescence-associated alternative splicing events. For each RBP, the enrichment of RNA binding information of the Alternative Splicing Event (ASE) regions compared with the non-ASE regions through combining the methods of motif scanning and eCLIP peaks. Only the differentially expressed RBPs with significantly enriched RNA binding information were defined as the potential senescence-associated regulators (right scatter plot). x-axis is the p-value of down-regulations of the RBPs, y axis is the combined enrichment p-value. Red point is the detected eight splicing RBPs.