Research Paper Volume 10, Issue 6 pp 1506—1522

Fanconi Anemia complementation group C protein in metabolic disorders

Figure 3. Metabolic functions and integrative molecular modeling for different diseases. (A) Top networks of metabolite markers, associated with molecular and cellular functions, were determined to be readouts of reduced cell signaling processes that are essentially to cancer and many specific disorders (gastrointestinal disease, organismal injury and abnormalities and others). (B) Altered metabolites were associated with cancer in FANCC-high cells in comparison with FANCC-low cells. The pink color-indicated metabolites (L-methionine, sphingomyelin, acetyl-L-carnitine, L-aspartic acid, L-glutamic acid, niacinamide and phosphorylethanolamine) were found to be elevated, which were the products of cancer inhibitory processes. Two metabolites labeled with green color were found to be lower, which were the end chemical substances of cancer promoting cellular processes. As summarized in the table shown at the bottom, 28 out of 30 metabolites were elevated in FANCC-high cells, and two were present at a lower level. Among 28 metabolites, 7 metabolites were known to be the readouts of cancer inhibitory cellular processes, and the rest of 23 were predicted to be in the inhibitory processes to cancer.