Research Paper Volume 10, Issue 6 pp 1506—1522

Fanconi Anemia complementation group C protein in metabolic disorders

Figure 4. Metabolic indication of FANCC functions in aging and inflammation. (A) Aging associated metabolites were altered in FANCC-high cells. Metabolites of aging inhibitory processes were significantly elevated in FANCC-high cells. Glycine, citrulline, ornithine, L-asparagine, L-tyrosine, L-arginine, L-glutamine, L-leucine, L-isoleucine, L-valine, L-alanine and L-proline were elevated in FANCC –high cells compared to FANCC-low cells. (B, C) Metabolites involved in inflammatory diseases: The most significantly differential network for inflammatory diseases, such as periodontitis, fulminant hepatitis and inflammation of liver, was indicated by the altered metabolites in FANCC-high cells. Inosine, L-isoleucine, L-leucine, L-lysine, l-phenylalanine, hypoxanthine and L-arginine were elevated in FANCC cells, which were involved in the inflammatory-inhibition processes and etc., as listed in the table shown at the side.