Research Paper Volume 10, Issue 8 pp 1964—1976

Circ-BPTF promotes bladder cancer progression and recurrence through the miR-31-5p/RAB27A axis

Figure 2. Circ-BPTF expression and its clinical significance in BCa. (A) The result of qPCR showed that circ-BPTF was up-regulated in BCa tissues compared to the adjacent normal tissues (P < 0.001). (B) Kaplan-Meier analysis demonstrated that patients with high circ-BPTF expression had poorer prognosis. Median expression of circ-BPTF in cancerous tissues was used as a cutoff value in survival analysis. (C) Expression of circ-BPTF in muscle invasive bladder cancer (MIBC) patients was notably higher than that in non-muscle invasive bladder cancer (NMIBC) patients (P<0.001). (D) Expression of circ-BPTF was significantly higher in patients with recurrence (P<0.05).