Research Paper Volume 10, Issue 8 pp 2062—2078

LncRNA BANCR promotes tumorigenesis and enhances adriamycin resistance in colorectal cancer

Figure 5G-N. BANCR acted as a molecular sponge of miR-203 to sequester miR-203 away from CSE1L in CRC cells. (G and H) The effects of BANCR knockdown and overexpression on miR-203 expression were assessed in LoVo and HCT116 cells. (I and J) LoVo and HCT116 cells were transfected with miR-Control, miR-203, miR-203+pcDNA-Control, or miR-203+pcDNA-BANCR, followed by the measurement of CSE1L protein level. (K) miR-203 expression in 32 paired CRC tumor tissues and adjacent non-cancerous tissues. (L and M) Correlation analysis between miR-203 and BANCR or CSE1L in 32 paired CRC tumor tissues. (N) The effects of CSE1L silencing on 53BP1 and FEN1 expressions were tested in HCT116 cells. *P < 0.05.