Research Paper Volume 10, Issue 8 pp 2062—2078

LncRNA BANCR promotes tumorigenesis and enhances adriamycin resistance in colorectal cancer

Figure 6. BANCR knockdown inhibited tumor growth and enhanced ADR sensitivity by modulation of miR-203/ CSE1L pathway in vivo. LoVo/DOX cells stably infected lenti-sh-XIST or lenti-sh-Control were subcutaneously inoculated into, followed by injection with the left flank of mice, ADR (1 mg/kg) every 3 days on day 6 after cell inoculation. (A) Tumor volume was determined at the indicated time points (6, 9, 12, 15, 18, 21 days) after first injection. (B) At 21 days upon cell implantation, tumors were excised, imaged and weighted. (C-E) Expressions of BANCR, miR-203 and CSE1L in xenograft tumors were determined by RT-qPCR and western blot assays. *P < 0.05.