Research Paper Volume 10, Issue 8 pp 2113—2121

MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway

Figure 1. Expression of miR-146b and PTEN in PCa tissues and cell lines. (A) The qRT-PCR results showed that miR-146b mRNA was significantly upregulated in PCa tissues compared to the matched adjacent non-tumor tissues. (B) The qRT-PCR results showed that miR-146b mRNA was significantly upregulated in PCa cell lines. (C) The qRT-PCR results showed that PTEN mRNA was significantly downregulated in PCa cell lines. (D-E) The western blot results showed that protein level of PTEN was significantly downregulated in PCa cell lines. (*P < 0.05, **P < 0.01***P < 0.001).