Research Paper Volume 10, Issue 8 pp 2113—2121

MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway

Figure 4. MiR-146b inhibited autophagy via the PTEN/AKT/mTOR signaling pathway in PCa cells. (A) Western blot results of the protein expression of LC3BI/II, P62, PTEN, p-AKT and p-mTOR in PC3 cells co-transfecting with miR-146b mimic, miR-146b inhibitor and negative control. (B-F) Quantification of the protein levels of LC3BI/II, P62, PTEN, p-AKT and p-mTOR. (*P < 0.05, **P < 0.01***P < 0.001).