Research Paper Volume 10, Issue 8 pp 2122—2135

A Drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention

Figure 2. Chronic CS exposure reduces the locomotor activity of male and female w1118 flies. Effect of 7d CS exposure on the locomotor activity (A, 36 hour period, B mean values) of male flies (p<0.0001, n=16). 14d CS exposure affects movement activities substantially (C, 36 hour period, D mean values). Effects of 7d CS exposure on the locomotor activity (E, 36 hour period, F mean values) of female flies. The morning peak of 7d CS exposed female flies is almost completely diminished, while the overall activity is not significantly decreased. 14d of CS exposure affects the movement activities more severely (G, 36 hour period, H mean values, p<0.0001, n = 16). Red symbols/bars mean CS exposed, black symbols/bars mean matching controls.