Figure 2. p62 DNA suppressed development of retinopathy and the effect persisted for 6 months after the last injection. (A) The data are presented as a.u. corresponding to the stages of retinopathy. *A significant increase in the severity of retinopathy according to the pairwise comparisons of the eye condition before and after treatment. (B) Stages of retinopathy in 4- and 10.5-month-old controls and p62 treated OXYS rats. Treatment was started at the age 1.5 months. In each group, 30 eyes of 15 animals were examined. The data are presented as the percentage of eyes with stages (0, 1, 2 and 3) of retinopathy.