Research Paper Volume 10, Issue 9 pp 2338—2355

Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice

Figure 1. Macroscopic phenotype of SAMP1/kl-deficient mice. (A) Gross appearance of deficient (SAMP1/kl-/-) mice at 4 weeks of age. (B) Body weight curves for 4- to 11-week-old Klotho-deficient (kl-/-) and compound-deficient (SAMP1/kl-/-) mice. (C) Survival curves for the groups of SAMP1/kl+/+ (n=6) and SAMP1/kl-/- (n=7) mice.