Research Paper Volume 10, Issue 9 pp 2338—2355

Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice

Figure 4. A comparison of the metabolic profile of mouse kidney tissues (SAMP1/kl+/+, SAMP1/kl-/-, and HL156A-treated SAMP1/kl-/-) was performed by CE-TOFMS. (A) Survival curves for the SAMP1/kl-/- and Hl156A-treated SAMP1/kl-/- mice. (B) The horizontal axis and vertical axis show the sample names and peaks, respectively. HCA was performed for the peaks. The distances between peaks are displayed in tree diagrams.