Research Paper Volume 10, Issue 9 pp 2407—2427

Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling

Figure 6. Schematic representation of the proposed mechanisms culminating in the replicative lifespan extension. Enhanced respiration, triggered by TORC1 inactivation, leads to increased superoxide production, which causes activation of antioxidant defenses and redox homeostasis maintenance (glutathione recycling), essential for heat-induced longevity.