Figure 1. “Super” chronic effects of maternal deprivation on brain function and behavior of mice. Early-life stress induces hypersensitivity, early-onset of cognitive function disorder, and neglect behavior of mothers. Early-life stress also induces the increase in the concentration of prolactin (PRL) during the perinatal period. Which potentially increases the concentration of corticosterone (CRT) in offspring. These changes possibly induce hypersensitivity and neglect behavior of offspring.