Research Paper Volume 10, Issue 10 pp 2585—2605

H3K9me3 and H4K20me3 represent the epigenetic landscape for 53BP1 binding to DNA lesions

Figure 11. Schematic illustration of protein levels in DNA lesions in wild-type and Suv39h1/h2 dn mouse embryonic fibroblasts. Colored dots illustrate the levels of selected proteins at UVA-irradiated chromatin. The illustration demonstrates the appearance of the following proteins at DNA lesions: HP1β (pink circles), H3K9me3 (orange circles), H3K9ac (dark green circles), H4K20me3 (red circles), γH2AX (pale green circles), and 53BP1 (white circles). The selected micro-irradiated ROI is shown by a white rectangle. The figure represents an illustration of our results.