Research Paper Volume 10, Issue 10 pp 2772—2782

Autophagy of macrophages is regulated by PI3k/Akt/mTOR signalling in the development of diabetic encephalopathy

Figure 7. Schematic. Diabetes induces increases in brain inflammatory macrophages, through increased PI3k/AKT/mTOR/S6K1 signalling and suppression of autophagy. mTOR and autophagy inhibit each other. RAP inhibits mTOR. CQ inhibits autophagy.