Research Paper Volume 10, Issue 10 pp 2874—2883

Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism

Figure 2. Learning and memory is impaired in APP mice. APP mice (n=11) and age-matched WT mice (n=12) were tested in MWM and NOR tests. (A) The escape latency was measured during the 4-day period. APP mice had a longer latency than WT mice. (B) The time spent in the target quadrant was measured on Day 5. APP mice spent much less time there than WT mice. (C) NOR discrimination index between APP and WT groups. *p< 0.05.