Figure 5. Body composition changes during an 8-month MSC lysate intervention (between session 4 and 8 at 17th and 28th months of age) for male rats. Survivors until 28 month of age were included for the Pre-Post comparison by Dual-energy x-ray absorptiometry (DEXA) analysis. Only male rats were measured due to consideration of technical limitation of the DEXA in size. Decreases in bone mass (A), bone density (B), fat mass (C) occurred in parallel with marginally increased bone-free lean mass (p = 0.06) (D). * Significant difference against the Vehicle group, p ≤ 0.05. Abbreviation: MSC, adipose-derived mesenchymal stem cell.