Research Paper Volume 10, Issue 10 pp 2954—2972

Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress

Figure 3. Melatonin promotes rhythmic expression of Nrf2. (A-C) Relative levels of Per2 (A) Bmal1 (B) and Nrf2 (C) in P0 and P11 cADMSCs. (D) Western blot quantification of MT1 and MT2 in control and melatonin-treated cADMSCs. (E-F) Relative levels of Bmal1 (E) and Nrf2 (F) in melatonin- and luzindole+melatonin-treated cADMSCs. (G-H) Relative levels of Grp78 in P0 and P11 (G) and melatonin-treated P11 (H) cADMSCs.