Research Paper Volume 10, Issue 10 pp 2973—2990

Quantitative characterization of biological age and frailty based on locomotor activity records

Figure 3. Hazards ratio models show high correlation with each other and are strongly associated with average level of physical activity and the largest variance in physiological measurements (PC1). (A) Scatter plots of estimated mortality hazard ratio (log-scale) vs PC1 scores and log-hazard ratio estimated by “LogMort” model trained on NHANES survival follow-up data shows high correlation (see text). (B) Different models for hazard ratio of mortality and morbidity show high correlation between each other and the PC1 "biological age" in NHANES samples. Models for mortality and morbidity were built using Cox proportional hazards method based on either NHANES or UKB death follow-up data and UKB follow-up on diagnosis. All values were adjusted by age and gender and thus represent the corresponding Biological Age Acceleration (BAA) values.